Catharnthus roseus is an evergreen subshrub or herbaceous plant growing 1 m (39 in) tall. The leaves are oval to oblong, 2.5–9 cm (1.0–3.5 in) long and 1–3.5 cm (0.4–1.4 in) broad, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm (0.4–0.7 in) long; they are arranged in opposite pairs.
The flowers are white to dark pink with a darker red centre, with a basal tube 2.5–3 cm (1.0–1.2 in) long and a corolla 2–5 cm (0.8–2.0 in) diameter with five petal-like lobes. The fruit is a pair of follicles 2–4 cm (0.8–1.6 in) long and 3 mm (0.1 in) broad.