Acalypha wilkesiana is a tropical and subtropical plant which grows naturally in Vanuatu and occurs in the Pacific Islands. It prefers light well-drained soil and is suited to a protected shady position. It can be damaged by both drought and frost. It needs a minimum temperature above 10 °C (50 °F). It is best suited to hardiness zones 9-12.
Propagation can be done by stem cuttings at any time of year, using bottom heat. It is used in mixed hedges and shrub borders and as a specimen shrub. Elsewhere copperleaf is grown as an annual where its spectacular foliage replaces flowers from late summer until frost. Copperleaf is also grown indoors as a container plant. However, it must be maintained in a warm, humid, bright environment.